Neural network cuts false-positive recalls

Published in MPW, 15 Aug 2014

Researchers in the US have developed an image-analysis technique that could cut the number of false-positive results in routine screening mammography. The technique, which uses a neural network to simultaneously analyse four different images, could save on costs associated with recalls, and relieve patients of undue worry (Phys. Med. Biol. 59 4357).

Routine mammography has been shown to significantly reduce mortality associated with breast cancer, which according to the World Health Organization is by far the most common cancer in women worldwide. Unfortunately, searching for true cases of malignant tumours among a majority of healthy women is a difficult task. Doctors naturally err on the side of caution, which means that of the 6 to 12% of women who are recalled, just one-tenth or fewer are truly in need of treatment. According to one study, in 10 years of screening more than half of women will experience a false-positive recall. […]

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Solar variation has little impact on cloud nuclei

Published in ERW, 17 Jul 2014

The Sun’s 11-year cycle of activity affects the formation of cloud condensation nuclei on Earth by less than 1%, according to a study performed in the US. The amplifying effect, although larger than some previous estimates, is still too small to account for the observed solar signature on the Earth’s temperature record.

The brightness of the Sun varies by about 0.1% over its 11-year cycle. Although this difference has left an observable signature on the Earth’s temperature over time, it is far too small to account for the majority of climate change on Earth. Confusingly, however, calculations show that the amplitude of the signature is 2.5 to 3 times too large for it to be caused by a direct heating effect. […]

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‘Quadrapeutics’ magnifies chemoradiation

Published in MPW, 17 Jul 2014

Nanoscopic explosions triggered by a laser can enhance the effectiveness of traditional cancer therapies by 10 to 100 times, according to scientists in the US who are pioneering the technique. “Quadrapeutics” appears to kill cancer cells while leaving healthy cells intact, and could prove especially good at targeting drug-resistant tumours and those in children (Nature Medicine 20 778).

Developed by biochemist Dmitri Lapotko at Rice University in Houston, TX, and colleagues, quadrapeutics is so called because it relies on the administration of four different components: chemotherapy drugs, gold nanoparticles, a laser pulse and X-ray radiation. At its heart, however, is the idea that tiny mechanical explosions – which the researchers call nanobubbles – amplify the effect of chemotherapy and radiotherapy, but only in cancerous cells. […]

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Cosmology surge keeps Europe ahead in dark matter research

Published in Horizon, 7 Jul 2014

A new wave of researchers is setting out to help shed light on the unseen forces shaping the universe, and keep Europe at the forefront of experimental cosmology.

Earlier this year, Dr Alexey Boyarsky at Leiden Observatory in the Netherlands discovered what could be indirect evidence of dark matter, while researchers at the European Space Agency (ESA) are now developing a probe that will try to measure dark energy, the unseen force believed to be driving the accelerated expansion of the universe. […]

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Rise of shine

Published in New Scientist, 5 Jul 2014

The solar cell of the future will be flexible, highly efficient and oh-so cheap – just as long as we can make it work in the rain

GOOD things come to those who wait, and Tsutomu Miyasaka had waited a long time. Knowing that a solar cell can be made using just about any pigment – coffee, chlorophyll, red wine – the Japanese physicist had spent years testing all sorts of colourful substances in the hope of finding one as efficient as it was cheap. Then, one day in April 2007, a student walked into his lab at the University of Tokyo, carrying a lump of an unremarkable mineral called perovskite.

It proved to be the start of something entirely remarkable. When Miyasaka reported the results from his first perovskite solar cell in 2009, it converted just 4 per cent of the sunlight’s energy to electricity. By 2012, the figure was over 10 per cent, and others were beginning to take notice. With groups around the world now on the case, efficiencies are touching 20 per cent, beating most solar cells currently on the market. “The field is moving so quickly – everyone is jumping on board,” says physicist Michael Johnston of the University of Oxford. Is this the solar technology everyone has been waiting for? […]

The rest of this article is available here.

Pooling funding to accelerate the move to smart electronics

Published in Horizon, 13 June 2014

If we want Europe to gain market share in developing technology for smart devices like phones and tablets, we must embrace public–private partnerships, according to Dr Andreas Wild, executive director of the EU’s new Electronic Components and Systems for European Leadership (ECSEL) Joint Technology Initiative.

Why is electronics so important to the EU?

‘Back in June 2011 the European Commission’s High-Level Group on Key Enabling Technologies recognised certain technologies as being important for Europe, and one of these technology areas was micro- and nanoelectronics, including semiconductors. In a nutshell, nanoelectronics provides the ‘smart’ in everything. If you have a smartphone, it’s smart because there’s a chip inside with software embedded in it and functionalities integrated around it. A smart card is not smart because of the fancy plastic, but because behind the gold pattern there is a chip with embedded software and integrated functionalities. Likewise, every smart object is smart because of the chip inside – and that’s micro- and nanoelectronics. There are economic implications of being able to make smart products, and there are also strategic implications in safety, security, autonomy and independence.’ […]

The rest of this article is published here.

Functional MRI tracks neurotransmitters

Published in MPW, 3 June 2013

Researchers in the US have for the first time used MRI to follow the dynamics of neurotransmitters with molecular precision. They have demonstrated the technique on dopamine, a neurotransmitter that represents processes of reward and motivation in the brain.

Neurotransmitters are the chemicals released at the end of nerve fibres to communicate signals to other nerve fibres in the vicinity. An understanding of their dynamics is important for a more general understanding of brain function, yet they are hard to study. In the past, scientists have resorted to PET, an imaging technique that relies on a radioactive tracer being inserted into the body so that its path can be monitored by emitted gamma rays. But PET can only supply images that are spatially accurate to within a few millimetres and temporally accurate to within a few minutes. […]

The rest of this article is available here.

Winds of change

Published in Physics World, 1 June 2014

The future of the wind industry is looking brighter thanks to a decades-old laser technology. Jon Cartwright explains how laser anemometry could cut the cost of wind energy and boost its share of the world’s energy market

On a coastal plain in Østerild, north Denmark, a gargantuan white structure turns solemnly in the breeze. The latest wind turbine designed by the Danish manufacturer Vestas, the V164, is the biggest yet: at 220m, it is well over twice the height of the Statue of Liberty. And when it was finally tested in Østerild at the beginning of 2014, it also proved to be the world’s most powerful – capable of generating 8 MW of power, enough to provide electricity for some 7500 homes.

The V164 is a symbol of the wind industry’s recent success. Over the past 14 years, the number of installed turbines across the world has risen dramatically, from an output of just 17 MW in 2000 to nearly 320000MW last year – corresponding to about 4% of the world’s total energy demand, according to the Global Wind Energy Council. The boom has been due partly to a surge in the construction of turbines in China, but many smaller countries are also adopting the technology. The UK, for example, generated 10% of its electricity from wind power last year, and it has more offshore wind capacity than the rest of the world combined.

Despite this success, however, the industry has sometimes struggled politically – not least because of a conflict between the cost and location of wind farms. Onshore wind power is relatively cheap: it costs about $87 per megawatt-hour, midway between natural gas ($66/MWh) and coal ($100/MWh), according to a 2013 report by the Energy Information Administration (an agency of the US Department of Energy). Plans for new onshore wind farms often face strong local opposition, however, which is why politicians frequently look offshore for new opportunities. But offshore wind is far more costly: the same 2013 report rates it as more expensive than nearly any other energy technology – renewable or otherwise – at about $222/MWh. The high cost of offshore wind was highlighted in March this year when Scottish and Southern Energy, a UK gas and electric company, announced that it would cut its investment in offshore turbines in order to assure a two-year price freeze for its customers. […]

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Shrinking electronics to its ultimate limit

Published in Horizon, 16 May 2014

Your laptop, smartphone or tablet could one day see a massive performance boost thanks to scientists who are shrinking electronics down to its ultimate limit: the size of single atoms or molecules.

All modern computing devices get their power from silicon chips, which are filled with transistors, and these transistors are very small – no more than a few dozen nanometres in diameter, or about a thousand times smaller than the width of a human hair.

However, for some people, that’s not small enough. Every two years or so, computer engineers have managed to double the number of transistors on chips in order to make the chips faster – a trend famously noted by the Intel Corporation co-founder Gordon Moore. To keep up with the squeeze, those engineers have had to employ smaller and smaller transistors.

That is why scientists are trying to make transistors and other electronic devices from single atoms and molecules. ‘An entire computer based on molecular electronics would overcome Moore’s Law,’ said physicist Angelika Kühnle at Johannes Gutenberg University in Mainz, Germany. […]

The rest of this article is available here.

Cerenkoscopy tested on human patient

Published in MPW, 7 May 2014

Cerenkoscopy – the monitoring of radiation therapy using Cerenkov radiation – has been tested on a human patient for the first time by scientists in the US. The technique, which involves capturing the flashes of Cerenkov light produced as radiation penetrates tissue, could improve the success of radiotherapy by visualizing radiation dose in real time (Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2014.01.046).

Side effects of radiation therapy can only be minimized by carefully regulating radiation doses, but knowing exactly how much radiation enters a body is not easy to assess. Normally, treatment is planned according to computer simulations generated by CT scans, and, at select points during a course of treatment, a patient can also have a detector inserted into them to estimate the amount of incident radiation. Such methods are not foolproof, however: a patient could lose weight, for instance, leading to a relatively high dose. […]

The rest of this article is available here.