Ramping radioluminescence resolution

Published in MPW, 1 Nov 2013

Scientists in the US have significantly improved the resolution of a technique used to image radionuclide uptake in individual living cells. Known as radioluminescence microscopy, the technique is now able to image the uptake of molecules even when two cells are very close together.

Radioluminescence microscopy was invented in 2010 by medical engineer Guillem Pratx and colleagues at Stanford University in California, to see how small molecules interact with living cells. Single molecules could already be seen with a technique known as fluorescence microscopy – but only if they were fluorescent. Pratx and colleagues wanted a technique that also worked for non-fluorescent molecules. […]

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